Polyether antibiotics synthesis. Total synthesis and absolute configuration of the ionophore A-23187
✍ Scribed by Evans, D. A.; Sacks, C. E.; Kleschick, W. A.; Taber, T. R.
- Book ID
- 120242998
- Publisher
- American Chemical Society
- Year
- 1979
- Tongue
- English
- Weight
- 388 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0002-7863
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The carboxylic acid antibiotic A-23187 (A) is a divalent cation ionophore which has been isolated from cultures of Streptomyces chartreusensis.' The structure and proposed absolute configuration2 have shown it to be one of a limited group of natural products, including oligomycin B3 and aplysiatoxin
## Abstract **Einladung zum T**: Erstmals wurde der T‐förmige Bisanthrachinon‐Naturstoff BE‐43472B durch Totalsynthese hergestellt und seine Absolutkonfiguration aufgeklärt. Wesentliche Schritte der zentralen Kaskadensequenz sind eine Diels‐Alder‐Reaktion, die Bildung eines Halbketals und eine nucl
## Abstract **An‐T‐biotic**: The first total synthesis of the T‐shaped bisanthraquinone natural product BE‐43472B was accomplished and its absolute configuration assigned. Key transformations in the pivotal cascade sequence include a Diels–Alder reaction, a hemiketal formation, and a nucleophilic a