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Polyether antibiotics synthesis. Total synthesis and absolute configuration of the ionophore A-23187

✍ Scribed by Evans, D. A.; Sacks, C. E.; Kleschick, W. A.; Taber, T. R.


Book ID
120242998
Publisher
American Chemical Society
Year
1979
Tongue
English
Weight
388 KB
Volume
101
Category
Article
ISSN
0002-7863

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📜 SIMILAR VOLUMES


Studies directed towards the total synth
✍ D.A. Evans; C.E. Sacks; R.A. Whitney; N.G. Mandel 📂 Article 📅 1978 🏛 Elsevier Science 🌐 French ⚖ 246 KB

The carboxylic acid antibiotic A-23187 (A) is a divalent cation ionophore which has been isolated from cultures of Streptomyces chartreusensis.' The structure and proposed absolute configuration2 have shown it to be one of a limited group of natural products, including oligomycin B3 and aplysiatoxin

Total Synthesis and Absolute Configurati
✍ K. C. Nicolaou; Yee Hwee Lim; Jochen Becker 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 449 KB

## Abstract **Einladung zum T**: Erstmals wurde der T‐förmige Bisanthrachinon‐Naturstoff BE‐43472B durch Totalsynthese hergestellt und seine Absolutkonfiguration aufgeklärt. Wesentliche Schritte der zentralen Kaskadensequenz sind eine Diels‐Alder‐Reaktion, die Bildung eines Halbketals und eine nucl

Total Synthesis and Absolute Configurati
✍ K. C. Nicolaou; Yee Hwee Lim; Jochen Becker 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 449 KB

## Abstract **An‐T‐biotic**: The first total synthesis of the T‐shaped bisanthraquinone natural product BE‐43472B was accomplished and its absolute configuration assigned. Key transformations in the pivotal cascade sequence include a Diels–Alder reaction, a hemiketal formation, and a nucleophilic a