A total synthesis of polyether antibiotic (−)-A23187 (calcimycin)
✍ Scribed by David P Negri; Yoshito Kishi
- Book ID
- 108382882
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 282 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The difference in the conformational behaviour of the two arms bearing the coordination sites, as shown by cristallographic studiesl 1, could be of importance for the transporting ability of calcimycin. To examine this point, we undertook the synthesis of a model incorporating an identical overall s
The carboxylic acid antibiotic A-23187 (A) is a divalent cation ionophore which has been isolated from cultures of Streptomyces chartreusensis.' The structure and proposed absolute configuration2 have shown it to be one of a limited group of natural products, including oligomycin B3 and aplysiatoxin