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Polyene macrolide antibiotic amphotericin B. Crystal structure of the N-iodoacetyl derivative

✍ Scribed by Ganis, Paolo; Avitabile, Gustavo; Mechlinski, Witold; Schaffner, Carl P.

Book ID
118200494
Publisher
American Chemical Society
Year
1971
Tongue
English
Weight
587 KB
Volume
93
Category
Article
ISSN
0002-7863

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πŸ“œ SIMILAR VOLUMES

Structure and absolute configuration of
Structure and absolute configuration of the polyene macrolide antibiotic amphotericin B
✍ W. Mechlinski; C.P. Schaffner; P. Ganis; G. Avitabile πŸ“‚ Article πŸ“… 1970 πŸ› Elsevier Science 🌐 French βš– 197 KB

As a result of the x-ray single crystal analysis of N-iodoacetylamphotericin B the chemical and stereochemical absolute structure ia presented (I). A similar etructure and stereochemistry wae extended to the parent compound itself, amphotericin B, a heptaene macrolide antifungal antibiotic possessin

Structure and absolute configuration of
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✍ W. Mechlenski; C.P. Shaffner; P. Ganis; G. Avitable πŸ“‚ Article πŸ“… 1970 πŸ› Elsevier Science 🌐 French βš– 27 KB

Tetrahedron Letters No. 41. pp. 3601-3604 (1970) p. 3529 W. Sprenger was omitted from the "Contributors to this issue" W. MECHLINSKI, C. P. SCHAFFNER, P. GANIS and G. AVITABILE: Structure and absolute configuration of the polyene macrolide antibiotic amphotericin B.

The structural elucidation of polyene ma
The structural elucidation of polyene macrolide antibiotics by mass spectrometry. Nystatin, amphotericin B and pimaricin
✍ Klaus D. Haegele; Dominic M. Desiderio Jr πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 English βš– 645 KB

Complete mass spectra of the pertrimethylsilylated derivatives of three high molecular weight polyene macrolide antibiotics are reported for the first time. The fragmentation pathways which are proposed have been corroborated by the stable isotope derivatives d,-TMS and d,-acetyl. Accurate mass meas

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Membrane effects of the polyene antibiotic amphotericin B and of some of its derivatives on lymphocytes
✍ N. Henry-ToulmΓ©; P. Sarthou; M. Seman; J. Bolard πŸ“‚ Article πŸ“… 1989 πŸ› Springer 🌐 English βš– 444 KB

Amphotericin B (AmB) exhibits immunomodulating properties in mice. In vitro studies on lymphocytes, in relation with these properties, are reported here with AmB and two of its derivatives: the N-Fructosyl (N-Fru AmB) and the N-thiopropionyl (AmBSH) derivatives. Interactions of these molecules with