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Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release

✍ Scribed by D. Mekahli; E. Sammels; T. Luyten; K. Welkenhuyzen; L.P. van den Heuvel; E.N. Levtchenko; R. Gijsbers; G. Bultynck; J.B. Parys; H. De Smedt; L. Missiaen


Book ID
113525970
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
431 KB
Volume
51
Category
Article
ISSN
0143-4160

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## Abstract In non‐excitable cells, the inositol 1,4,5‐trisphosphate receptor (IP~3~R), a ligand‐gated Ca^2+^ channel, plays an important role in the control of intracellular Ca^2+^. There are three subtypes of IP~3~R that are differentially distributed among cell types. AR4‐2J cells express almost