𝔖 Bobbio Scriptorium
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Poly(ADP-ribosyl)ation studies in situ

✍ Scribed by David M. Duhl; Lubomir S. Hnilica

Book ID
107714317
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
816 KB
Volume
156
Category
Article
ISSN
0003-2697

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One of the immediate eukaryotic cellular responses to DNA breakage is the covalent post-translational modification of nuclear proteins with poly(ADP-ribose) from NAD+ as precursor, mostly catalysed by poly(ADP-ribose) polymerase-1 (PARP-1). Recently several other polypeptides have been shown to cata