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Poly(ADP-ribosyl)ation and aging

✍ Scribed by Alexander Bürkle; Sascha Beneke; Marie-Laure Muiras


Book ID
113614555
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
108 KB
Volume
39
Category
Article
ISSN
0531-5565

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One of the immediate eukaryotic cellular responses to DNA breakage is the covalent post-translational modification of nuclear proteins with poly(ADP-ribose) from NAD+ as precursor, mostly catalysed by poly(ADP-ribose) polymerase-1 (PARP-1). Recently several other polypeptides have been shown to cata