𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Poly-L-lactic acid/hydroxyapatite hybrid membrane for bone tissue regeneration

✍ Scribed by Gang Sui; Xiaoping Yang; Fang Mei; Xiaoyang Hu; Guoqiang Chen; Xuliang Deng; Seungkon Ryu

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
656 KB
Volume
82A
Category
Article
ISSN
1549-3296

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Poly‐L‐lactic acid (PLLA)/hydroxyapatite (HA) hybrid membranes were fabricated via electrospinning of the PLLA/HA dispersion for use in bone tissue regeneration. The structural properties and morphologies of PLLA and PLLA/HA hybrid membrane were investigated by measuring the Brunauer‐Emmett‐Teller specific surface area, observations of SEM, and TEM. The dispersion and integrating of HA nanoparticles in the hybrid membrane were studied by energy dispersion X‐ray analysis and FTIR. The mechanical properties of PLLA/HA membrane were also measured by tensile tests. For exploring biological behaviors of the hybrid membrane, in vitro degradation tests were carried out. The osteoblast cell (MG‐63) was cultured in PLLA/HA hybrid membrane extract containing medium; the cell adhesion and growth capability were investigated by SEM observation and MTT assay. HA nanoparticles were not only dispersed in the PLLA but also reacted with the functional group of PLLA, resulting in strong surface bonding and high tensile strength of hybrid membrane. The cell adhesion and growth on the PLLA/HA hybrid membrane were far better than those on the pure PLLA membrane, which proves that the PLLA/HA hybrid membrane can be one of the promising biomaterials for bone tissue regeneration. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

📜 SIMILAR VOLUMES

Chitosan/poly(L-lactic acid) multilayere
Chitosan/poly(L-lactic acid) multilayered membrane for guided tissue regeneration
✍ Young Ku; In Kyong Shim; Jue Yoen Lee; Yoon Jeong Park; Sang-Hoon Rhee; Sung Heo 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 370 KB

## Abstract A chitosan/poly(L‐lactic acid) (PLLA) multilayered membrane was prepared for the purpose of guided tissue regeneration (GTR). The membrane was composed of the outer layers of chitosan mesh and the middle layer of nanoporous PLLA membrane. The outer membranes of chitosan fibrous mesh pre

Nanofibrous Poly(lactic acid)/Hydroxyapa
Nanofibrous Poly(lactic acid)/Hydroxyapatite Composite Scaffolds for Guided Tissue Regeneration
✍ Sung In Jeong; Eun Kyoung Ko; Jungsuk Yum; Chul Ho Jung; Young Moo Lee; Heungsoo 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 384 KB

## Abstract The production of nanofibrous PLA/HA composite scaffolds is described. The morphological, mechanical, surface, and thermal properties of the composites were extensively investigated. The results show that the mixture of PLA and HA formed smooth nanofibers without lumps. The incorporatio

Electrospinning biomedical nanocomposite
Electrospinning biomedical nanocomposite fibers of hydroxyapatite/poly(lactic acid) for bone regeneration
✍ Hae-Won Kim; Hae-Hyoung Lee; J. C. Knowles 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 607 KB

## Abstract Development of fibrous matrices of bioceramic–biopolymer nanocomposite offers great potential in the field of bone regeneration and tissue engineering. However, in order to produce electrospun fibers with homogeneous structure, it is essential for the ceramic powder to be fine and to re

Surface-engineered hydroxyapatite nanocr
Surface-engineered hydroxyapatite nanocrystal/ poly(ε-caprolactone) hybrid scaffolds for bone tissue engineering
✍ So Yeon Kim 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 537 KB

## Abstract To achieve novel polymer/bioceramic composite scaffolds for use in materials for bone tissue engineering, we prepared organic/inorganic hybrid scaffolds composed of biodegradable poly(ε‐caprolactone) (PCL) and hydroxyapatite (HA), which has excellent biocompatibility with hard tissues a

Fabrication and characterization of poly
Fabrication and characterization of poly(D,L-lactide-co-glycolide)/hydroxyapatite nanocomposite scaffolds for bone tissue regeneration
✍ Neda Aboudzadeh; Mohammad Imani; Mohammad Ali Shokrgozar; Alireza Khavandi; Jafa 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 488 KB

## Abstract Conventional methods in fabrication of scaffolds based on polymer/bioceramic composites frequently make use of solution casting then particle leaching. The residues of common organic solvents can get trapped in this technique hence provide safety concerns on final scaffold. In this stud