𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Electrospinning biomedical nanocomposite fibers of hydroxyapatite/poly(lactic acid) for bone regeneration

✍ Scribed by Hae-Won Kim; Hae-Hyoung Lee; J. C. Knowles

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
607 KB
Volume
79A
Category
Article
ISSN
1549-3296

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Development of fibrous matrices of bioceramic–biopolymer nanocomposite offers great potential in the field of bone regeneration and tissue engineering. However, in order to produce electrospun fibers with homogeneous structure, it is essential for the ceramic powder to be fine and to remain stable in suspension. Herein, we developed a novel method whereby the bioceramic hydroxyapatite (HA) was kept in suspension in biopolymer poly(lactic acid) (PLA). The strategy was to introduce a surfactant hydroxysteric acid (HSA) between the hydrophilic HA powder and the hydrophobic chloroform‐dissolved PLA. The HA nanopowder was dispersed effectively in HSA and mixed homogeneously with PLA. Continuous and uniform fibers were generated successfully with diameters of ∼1–2 μm, and featured a well‐developed nanocomposite structure of HA nanopowder‐dispersed PLA. Initial cellular assays showed excellent cell attachment and proliferation and also enhanced expression of alkaline phosphatase at 7 days of culturing. The HA–PLA nanocomposite fibers may be potentially useful in tissue engineering applications, particularly as three‐dimensional substrates for bone growth. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006

📜 SIMILAR VOLUMES

Poly-L-lactic acid/hydroxyapatite hybrid
Poly-L-lactic acid/hydroxyapatite hybrid membrane for bone tissue regeneration
✍ Gang Sui; Xiaoping Yang; Fang Mei; Xiaoyang Hu; Guoqiang Chen; Xuliang Deng; Seu 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 656 KB

## Abstract Poly‐L‐lactic acid (PLLA)/hydroxyapatite (HA) hybrid membranes were fabricated via electrospinning of the PLLA/HA dispersion for use in bone tissue regeneration. The structural properties and morphologies of PLLA and PLLA/HA hybrid membrane were investigated by measuring the Brunauer‐Em

Novel three-dimensional scaffolds of pol
Novel three-dimensional scaffolds of poly(L-lactic acid) microfibers using electrospinning and mechanical expansion: Fabrication and bone regeneration
✍ In Kyong Shim; Mi Ra Jung; Kyung Hwa Kim; Yang Jo Seol; Yoon Jeong Park; Won Ho 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 954 KB

## Abstract Poly(L‐lactic acid) (PLLA) microfibrous scaffolds with three‐dimensional (3D) structures were fabricated using an electrospinning technique with a subsequent mechanical expansion process. To achieve a 3D fibrous structure, the fusion at the contact points of the as‐spun PLLA microfibers

Fabrication and characterization of poly
Fabrication and characterization of poly(D,L-lactide-co-glycolide)/hydroxyapatite nanocomposite scaffolds for bone tissue regeneration
✍ Neda Aboudzadeh; Mohammad Imani; Mohammad Ali Shokrgozar; Alireza Khavandi; Jafa 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 488 KB

## Abstract Conventional methods in fabrication of scaffolds based on polymer/bioceramic composites frequently make use of solution casting then particle leaching. The residues of common organic solvents can get trapped in this technique hence provide safety concerns on final scaffold. In this stud

Fabrication, characterization, and in vi
Fabrication, characterization, and in vitro evaluation of poly(lactic acid glycolic acid)/nano-hydroxyapatite composite microsphere-based scaffolds for bone tissue engineering in rotating bioreactors
✍ Qing Lv; Lakshmi Nair; Cato T. Laurencin 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 680 KB

## Abstract Dynamic flow culture bioreactor systems have been shown to enhance __in vitro__ bone tissue formation by facilitating mass transfer and providing mechanical stimulation. Our laboratory has developed a biodegradable poly (lactic acid glycolic acid) (PLAGA) mixed scaffold consisting of li