𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Polo-like kinases in the nervous system

✍ Scribed by Seeburg, Daniel P; Pak, Daniel; Sheng, Morgan


Book ID
110069339
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
209 KB
Volume
24
Category
Article
ISSN
0950-9232

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A Pan-Specific Inhibitor of the Polo-Box
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## Abstract **Playing polo**: Small‐molecule inhibitors of polo‐like kinase 1 are mostly ATP‐competitive, and thus face enormous specificity hurdles. This communication explores the concept of inhibiting Plk1 with a small‐molecule inhibitor of the protein–protein interactions required for Plk1 func