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A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis

✍ Scribed by Wolfgang Reindl; Juping Yuan; Andrea Krämer; Klaus Strebhardt ; Thorsten Berg

Book ID
101820664
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
386 KB
Volume
10
Category
Article
ISSN
1439-4227

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✦ Synopsis

Abstract

Playing polo: Small‐molecule inhibitors of polo‐like kinase 1 are mostly ATP‐competitive, and thus face enormous specificity hurdles. This communication explores the concept of inhibiting Plk1 with a small‐molecule inhibitor of the protein–protein interactions required for Plk1 function.magnified image

📜 SIMILAR VOLUMES

Cover Picture: A Pan-Specific Inhibitor
Cover Picture: A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis (ChemBioChem 7/2009)
✍ Wolfgang Reindl; Juping Yuan; Andrea Krämer; Klaus Strebhardt ; Thorsten Berg 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 664 KB

## Abstract **The cover picture shows** the small molecule Poloxipan, a pan‐specific inhibitor of polo‐like kinases (Plks), and its effects on human cancer cells. Most inhibitors of protein kinases such as Plk1, which is a key player in mitosis, inhibit the enzyme ATP‐binding pocket. Due to the con