𝔖 Bobbio Scriptorium
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Polo-like kinases and the orchestration of cell division

✍ Scribed by Barr, Francis A.; Silljé, Herman H. W.; Nigg, Erich A.


Book ID
109958150
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
268 KB
Volume
5
Category
Article
ISSN
1471-0072

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## Abstract **Playing polo**: Small‐molecule inhibitors of polo‐like kinase 1 are mostly ATP‐competitive, and thus face enormous specificity hurdles. This communication explores the concept of inhibiting Plk1 with a small‐molecule inhibitor of the protein–protein interactions required for Plk1 func