✦ LIBER ✦

Polarized expression of major histocompatibility complex class I molecules in human endometrial and endocervical epithelial cells

✍ Scribed by Marion A. Van Eijkeren; Peter J. Peters; Hans J. Geuze

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 458 KB
Volume: 21
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830211223

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✦ Synopsis

Polarized expression of major histocompatibility complex class I molecules in human endometrial

Department of Obstetrics and and endocervical epithelial cells

Gynaecologyn and Laboratory of

Utrecht, Utrecht

The localization of major histocompatibility complex (MHC) class I molecules in human endometrial and endocervical epithelial cells was studied with an immunogold technique on ultrathin cryosections. At the cell surface, MHC class I molecules are delivered solely to the basolateral plasma membrane in human epithelia. Therefore, only the basolateral domain of epithelial cells is capable of presenting antigen to MHC class I-restricted cytotoxic T cells.

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