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Human herpesvirus 6 downregulates major histocompatibility complex class I in dendritic cells

✍ Scribed by Yuko Hirata; Kazuhiro Kondo; Koichi Yamanishi

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
201 KB
Volume
65
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

The expression of major histocompatibility complex (MHC) class I, class II, CD1a, and CD 83 in dendritic cells (DCs) after infection with human herpesvirus 6 (HHV‐6) was examined. Whereas there was no significant change in the expression of CD1a, CD83, and MHC class II in infected DCs, MHC class I expression was downregulated after infection with HHV‐6 variant A but not HHV‐6B. The expression of HHV‐6 immediate‐early or early genes was required for the downregulation of MHC class I. The de novo synthesis of MHC class I was greatly suppressed by infection with HHV‐6A in DCs, while its rate of degradation was only slightly elevated. These results suggest that HHV‐6A may escape from the host immune system in DCs by causing the downregulation of MHC class I synthesis. J. Med. Virol. 65:576–583, 2001. © 2001 Wiley‐Liss, Inc.

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