Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers
β Scribed by Cairns, Paul; Evron, Ella; Okami, Kenji; Halachmi, Naomi; Esteller, Manel; Herman, James G; Bose, Shikha; Wang, Steven I; Parsons, Ramon; Sidransky, David
- Book ID
- 110061361
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 316 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Neuroblastoma is the most common pediatric solid tumor. Although many allelic imbalances have been described, a bona fide tumor suppressor gene for this disease has not been found yet. In our study, we analyzed 2 genes, PTEN and DMBT1, mapping 10q23.31 and 10q25.3β26.1, respectively, wh
The PTEN/MMAC1 gene, located on human chromosome 10q23, has recently been implicated as a candidate tumor suppressor gene in human cancers. In the present study, 12 uterine cancer cell lines and 87 uterine cancers of various grades and histological type were analyzed for PTEN/MMAC1 gene. Three of 44