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Platelet-derived growth factor may be associated with fibrosis in a Down syndrome patient with transient myeloproliferative disorder

✍ Scribed by Jiro Ogawa; Hirokazu Kanegane; Koichi Tsuneyama; Rika Kanezaki; Takeshi Futatani; Keiko Nomura; Shin Ishizawa; Masakiyo Sasahara; Etsuro Ito; Toshio Miyawaki


Book ID
114794392
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
474 KB
Volume
81
Category
Article
ISSN
0902-4441

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## Abstract An infant with Down syndrome (DS) and RH isoimmunization developed transient myeloproliferative disorder (TMD) during the neonatal period. At 16 months she presented with acute nonlymphocytic leukemia (ANLL). Cytogenetic studies during TMD showed trisomy 21 only but new abnormalities em