Our previous studies have shown that steady shear stress causes a transient increase of platelet-derived growth factor (PDGF) A and B chain mRNA levels in human umbilical vein endothelial cells (HUVEC). In the present study, we elucidated the signaling pathway of shear stress in HUVEC by examining t
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein
β Scribed by Kruijer, Wiebe; Cooper, Jonathan A.; Hunter, Tony; Verma, Inder M.
- Book ID
- 109737571
- Publisher
- Nature Publishing Group
- Year
- 1984
- Tongue
- English
- Weight
- 941 KB
- Volume
- 312
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/312711a0
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Mutations in the WTI tumor suppressor gene are known t o contribute t o the development of Wilms' tumor (WT) and associated gonadal abnormalities. WTI is expressed principally in the fetal kidney, developing gonads, and spleen and also in the mesothelium, which lines the coelomic cavities. These tis
Previously we showed a rapid and transient inhibition of gap junctional communication (GJC) by platelet-derived growth factor (PDGF) in T51B rat liver epithelial cells expressing wild-type platelet-derived growth factor b receptors (PDGFrb). This action of PDGF correlated with the hyperphosphorylati