## Abstract VHL is the causative gene for von Hippel‐Lindau disease and sporadic clear cell renal cancer. It has been shown that pVHL can suppress the expression of certain genes that are overexpressed in renal carcinomas. One such gene is that encoding the potent mitogen and chemoattractant, plate
Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression
✍ Scribed by Finkenzeller, Günter; Sparacio, Angelica; Technau, Antje; Marmé, Dieter; Siemeister, Gerhard
- Book ID
- 110060824
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 373 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Mutations in the WTI tumor suppressor gene are known t o contribute t o the development of Wilms' tumor (WT) and associated gonadal abnormalities. WTI is expressed principally in the fetal kidney, developing gonads, and spleen and also in the mesothelium, which lines the coelomic cavities. These tis
## Abstract ## Background Neoangiogenesis is essential for tumor growth. The present study aimed to test the hypothesis that vector‐mediated expression of sflt1 at high levels would result in the blockade of vascular endothelial growth factor (VEGF) function and therefore the inhibition of tumor g