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Platelet-activating factor stimulates expression of IL-1 beta mRNA in THP-1 cells

✍ Scribed by Roger A. Barthelson; Frank H. Valone

Book ID
112777437
Publisher
Springer-Verlag
Year
1991
Tongue
English
Weight
620 KB
Volume
26
Category
Article
ISSN
0024-4201

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## Platelet -activating factor (PAF) elicits a rapid and transient activation of the proto-oncogenes c-fos and cjun in SH-SYSY neuroblastoma cells, but only to a minor extent in Molt-4 T-lymphocytes. This effect is inhibited by pretreatment of cells with the PAF antagonist BN 52021, suggesting the