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Platelet-activating factor stimulates a Fos/Jun/AP-1 transcriptional signaling system in human neuroblastoma cells

✍ Scribed by S. P. Squinto; A. L. Block; P. Braquet; N. G. Bazan

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
872 KB
Volume
24
Category
Article
ISSN
0360-4012

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✦ Synopsis

Platelet

-activating factor (PAF) elicits a rapid and transient activation of the proto-oncogenes c-fos and cjun in SH-SYSY neuroblastoma cells, but only to a minor extent in Molt-4 T-lymphocytes. This effect is inhibited by pretreatment of cells with the PAF antagonist BN 52021, suggesting the involvement of a specific receptor. Moreover, PAF treatment can activate gene expression through an AP-1 element, and we propose that genomic trans-activation may occur in target genes containing a functional AP-1 transcription sequence. These results may further understanding of the molecular mechanisms by which PAF contributes to long-term phenotypic changes in the nervous system.

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