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Transforming growth factor-beta 1 stimulates angiotensinogen gene expression in kidney proximal tubular cells

✍ Scribed by Brezniceanu, M-L; Wei, C-C; Zhang, S-L; Hsieh, T-J; Guo, D-F; Hébert, M-J; Ingelfinger, J R; Filep, J G; Chan, J S D

Book ID
110052785
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
193 KB
Volume
69
Category
Article
ISSN
0085-2538

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## Abstract Biglycan is a small leucine‐rich proteoglycan which is localized in the extracellular matrix of bone and other specialized connective tissues. Both biglycan mRNA and protein are up‐regulated by transforming growth factor‐β~1~ (TGF‐β~1~) and biglycan appears to influence TGF‐β~1~ activit