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Plasminogen activation by recombinant tissue plasminogen activator and potentiation by fibrin: a refined kinetic analysis

✍ Scribed by N. Willmott; P. Gaffney

Book ID
114201014
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
442 KB
Volume
9
Category
Article
ISSN
0268-9499

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit