Plasma protein binding of highly bound drugs: Implications of radiochemical impurities
β Scribed by Amita S. Joshi; Henry J. Pieniaszek Jr.; Check Y. Quon; Shang-Ying P. King
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 258 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0022-3549
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The aim of this work was to provide a short overview of existing methods for the determination of free drug concentration and protein-drug binding fraction in plasma. Various methods have been described in terms of principles, evaluation of methods, and applications in recent years, with an emphasis
The plasma protein binding of drugs has been shown to have significant effects on the quantitative relationship between clinical pharmacokinetics and pharmacodynamics. In many clinical situations, measurement of the total drug concentration does not provide the needed information concerning the unbo