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Determination of unbound drug concentration and protein–drug binding fraction in plasma

✍ Scribed by Zhisong Liu; Famei Li; Yuesheng Huang

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
52 KB
Volume
13
Category
Article
ISSN
0269-3879

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✦ Synopsis

The aim of this work was to provide a short overview of existing methods for the determination of free drug concentration and protein-drug binding fraction in plasma. Various methods have been described in terms of principles, evaluation of methods, and applications in recent years, with an emphasis on the chromatographic method, i.e. high-performance frontal analysis (HPFA).

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