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Plasma morphine concentration-analgesic relationship in the rat after codeine and morphine

✍ Scribed by Chen, Z.R.; Ritchie, R.; Irvine, R.J.; Bochner, F.; Somogyi, A.


Book ID
122350163
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
99 KB
Volume
41
Category
Article
ISSN
0304-3959

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Objective: The analgesic effect of codeine depends on its O-demethylation to morphine via sparteine oxygenase (CYP2D6) in the liver and presumably also via this enzyme in the CNS. We studied the ability of quinidine, which is a potent inhibitor of CYP2D6, to penetrate the blood brain barrier and its