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Plasma Codeine and Morphine Concentrations After a Single Oral Dose of Codeine Phosphate

✍ Scribed by Shah, Jaymin C.; Mason, William D.

Book ID
121714249
Publisher
Sage Publications
Year
1990
Tongue
English
Weight
485 KB
Volume
30
Category
Article
ISSN
0091-2700

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Impact of quinidine on plasma and cerebr
Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake
✍ S. H. Sindrup; K. BrΓΈsen; F. Nielsen; U. Hofmann; G. Mikus; J. Asmussen; S. H. I πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 609 KB

Objective: The analgesic effect of codeine depends on its O-demethylation to morphine via sparteine oxygenase (CYP2D6) in the liver and presumably also via this enzyme in the CNS. We studied the ability of quinidine, which is a potent inhibitor of CYP2D6, to penetrate the blood brain barrier and its