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Analgesic effect and plasma concentrations of codeine and morphine after two dose levels of codeine following oral surgery

✍ Scribed by H. Quiding; G. Lundqvist; L. O. Boréus; U. Bondesson; J. Öhrvik


Publisher
Springer
Year
1993
Tongue
English
Weight
543 KB
Volume
44
Category
Article
ISSN
0031-6970

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Objective: The analgesic effect of codeine depends on its O-demethylation to morphine via sparteine oxygenase (CYP2D6) in the liver and presumably also via this enzyme in the CNS. We studied the ability of quinidine, which is a potent inhibitor of CYP2D6, to penetrate the blood brain barrier and its