Plaques, Tangles, and Memory Loss in Mouse Models of Neurodegeneration
✍ Scribed by Jason L. Eriksen; Christopher G. Janus
- Book ID
- 106359635
- Publisher
- Springer US
- Year
- 2006
- Tongue
- English
- Weight
- 462 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0001-8244
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The BALB/c mouse model of Niemann‐Pick type C (NPC) disease exhibits neuropathological similarities to the human condition. There is an age‐related cerebral atrophy, demyelination of the corpus callosum, and degeneration of cerebellar Purkinje cells in the NPC mouse. In human NPC, many
## Abstract Accumulating evidence has indicated that gain‐of‐function in β‐amyloid production may be not the necessary mechanism for mutant presenilin‐1 (PS1) or PS2 to cause familial Alzheimer's disease (AD). In the present article, we show that conditional knockout of PS1 from the adult stage in
## Abstract We performed three‐dimensional, high‐resolution magnetic resonance imaging (MRI) of fixed mouse brains to determine whether MRI can detect amyloid plaques in transgenic mouse models of Alzheimer's disease. Plaque‐like structures in the cortex and hippocampus could be clearly identified