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Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging

✍ Scribed by Jiangyang Zhang; Paul Yarowsky; Marcia N. Gordon; Giovanni Di Carlo; Sanjay Munireddy; Peter C.M. van Zijl; Susumu Mori

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
639 KB
Volume
51
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

We performed three‐dimensional, high‐resolution magnetic resonance imaging (MRI) of fixed mouse brains to determine whether MRI can detect amyloid plaques in transgenic mouse models of Alzheimer's disease. Plaque‐like structures in the cortex and hippocampus could be clearly identified in T~2~‐weighted images with an image resolution of 46 μm × 72 μm × 72 μm. The locations of plaques were confirmed in coregistration studies comparing MR images with Congo red‐stained histological results. This technique is quantitative, less labor‐intensive compared to histology, and is free from artifacts related to sectioning process (deformation and missing tissues). It enabled us to study the distribution of plaques in the entire brain in 3D. The results of this study suggest that this method may be useful for assessing treatment efficacy in mouse models of Alzheimer's disease (AD). Magn Reson Med 51:452–457, 2004. © 2004 Wiley‐Liss, Inc.

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