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Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice

✍ Scribed by George R Lankas; L.David Wise; Mark E Cartwright; Todd Pippert; Diane R Umbenhauer

Book ID: 114274202
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 300 KB
Volume: 12
Category: Article
ISSN: 0890-6238
DOI: 10.1016/s0890-6238(98)00027-6

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## Abstract Acute apoptotic response to genotoxic carcinogens (AARGC) might be important for controlling the consequences of mutational load in the colon. It has been shown to occur in parallel with activation of DNA repair mechanisms. Inadequate AARGC might allow development of mutated clones with