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Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice

✍ Scribed by Joann P Palma; Hee-Gu Lee; Mani Mohindru; Bong-Su Kang; Mauro Dal Canto; Stephen D Miller; Byung S Kim


Book ID
114137366
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
951 KB
Volume
116
Category
Article
ISSN
0165-5728

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## Abstract Intracerebral inoculation of Theiler's murine encephalomyelitis virus (TMEV) results in immune‐mediated demyelination in selective mouse strains. We have previously demonstrated that the males of C57L mice are significantly more susceptible to TMEV‐induced demyelinating disease. To asse