Pilot study of escalating doses of carboplatin and cyclophosphamide in patients with advanced cancer
β Scribed by Russell L. Basser; Michael D. Green; William P. Sheridan; Richard M. Fox
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 273 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## BACKGROUND The authors performed a dose escalation study of cisplatin and the novel deoxycytidine analog, tezacitabine, to determine the maximum tolerated dose of the combination. ## METHODS Twentyβthree patients with advanced cancer and good performance status were accrued to 3 d
## BACKGROUND. We performed a Phase 1-11 trial to determine the maximum tolerated dose of carboplatin (CBDCA) with a fixed dose of VP-16 and granulocyte-colony stimulating factor (G-CSF) in small cell lung cancer (SCLC) patients. ## METHODS. Treatment consisted of a starting dose of CBDCA, 400