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Physiology and pathology of notch signalling system

✍ Scribed by Silvia Bianchi; Maria Teresa Dotti; Antonio Federico

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
185 KB
Volume
207
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Notch proteins encode a family of transmembrane receptors that are part of a signalling transduction system known as Notch signalling, an extremely conserved and widely used mechanism regulating programs governing growth, apoptosis and differentiation in metazoans. Notch signalling begins when the Notch receptor binds ligands and ends when the Notch intracellular domain enters the nucleus and activates transcription of target genes. This core pathway is subjected to a wide array of regulatory influences and protein‐protein interactions and is correlated with other signalling pathway. This review will sumarize recent findings concerning the physiology and pathology of Notch signalling in vascular development and homeostasis. Moreover, the clinical phenotypes of Notch3 signalling system pathology will be described, with particular regard to CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) for which the most recent pathogenetic hypotheses are reported. J. Cell. Physiol. 207: 300–308, 2006. © 2005 Wiley‐Liss, Inc.

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