𝔖 Bobbio Scriptorium
✦   LIBER   ✦

TGF?/Smad signaling system and its pathologic correlates

✍ Scribed by Cohen, M. Michael

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
181 KB
Volume
116A
Category
Article
ISSN
0148-7299

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

TGF-β signaling, Smads, and tumor suppre
TGF-β signaling, Smads, and tumor suppressors
✍ Richard W. Padgett; Pradeep Das; Srikant Krishna 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 262 KB

The transforming growth factor-␤ (TGF-␤) superfamily is used throughout animal development for regulating the growth and patterning of many tissue types. During the past few years, rapid progress has been made in deciphering how TGF-␤ signals are transduced from outside the cell to the nucleus. This

Intracellular dynamics of Smad-mediated
Intracellular dynamics of Smad-mediated TGFβ signaling
✍ Robert M. Greene; Paul Nugent; Partha Mukhopadhyay; Dennis R. Warner; M. Michele 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 306 KB

## Abstract The transforming growth factor‐β (TGFβ) family represents a class of signaling molecules that plays a central role in morphogenesis, growth, and cell differentiation during normal embryonic development. Members of this growth factor family are particularly vital to development of the ma

Structural insights on Smad function in
Structural insights on Smad function in TGFβ signaling
✍ Yigong Shi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 325 KB 👁 1 views

TGFbeta signaling plays a central role in regulating a broad range of cellular responses in a variety of organisms. TGFbeta signaling from the cell membrane to the nucleus is mediated by the Smad family of proteins. During the past five years of intense investigation, key events in TGFbeta signaling

Identification of the gene transcription
Identification of the gene transcription and apoptosis mediated by TGF-β-Smad2/3-Smad4 signaling
✍ Jian Yu; Liang Zhang; Ailiang Chen; Guangxin Xiang; Yahui Wang; Jianping Wu; Kei 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 416 KB

## Abstract Transforming growth factor‐β (TGF‐β) signaling is known to depend on the formation of Smad2/3‐Smad4 transcription regulatory complexes. However, the signaling functions of Smad2/3‐Smad4 during TGF‐β‐induced responses are obscure as TGF‐β also initiates a number of other signaling pathwa

A tale of two proteins: Differential rol
A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF-β signaling
✍ Kimberly A. Brown; Jennifer A. Pietenpol; Harold L. Moses 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 396 KB

## Abstract Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells, and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. Smad2 and Smad3 are direct mediators of TGF‐β signaling, however little is kno

Transcriptional regulation of Smad2 is r
Transcriptional regulation of Smad2 is required for enhancement of TGFβ/Smad signaling by TGFβ inducible early gene
✍ Steven A. Johnsen; Malayannan Subramaniam; Takenobu Katagiri; Ralf Janknecht; Th 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 178 KB

TGFbeta inducible early gene (TIEG) is a novel Krüppel-like transcriptional repressor that was recently shown to increase the activity of the TGFbeta/Smad signal transduction pathway by relieving negative feedback through repression of the inhibitory Smad7. Interestingly, while Smad7 is required for