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Physiologically based pharmacokinetic (PB-PK) models in the study of the disposition and biological effects of xenobiotics and drugs

✍ Scribed by Melvin E. Andersen

Book ID
118411902
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
731 KB
Volume
82-83
Category
Article
ISSN
0378-4274

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Disposition of p-phenylbenzoic acid (PPBA) in the pregnant Wistar rat (for both mother and fetuses) was predicted by using a physiologically based pharmacokinetic model. This model was constructed from ten organs for the mother and eight organs for fetuses, with fetal blood flow based on anatomical