𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Reduction and Lumping of Physiologically Based Pharmacokinetic Models: Prediction of the Disposition of Fentanyl and Pethidine in Humans by Successively Simplified Models

✍ Scribed by Sven Björkman

Book ID
111558415
Publisher
Springer
Year
2003
Tongue
English
Weight
247 KB
Volume
30
Category
Article
ISSN
1573-8744

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Prediction of pharmacokinetics prior to
Prediction of pharmacokinetics prior to In Vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition
✍ Patrick Poulin; Frank-Peter Theil 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 179 KB

Many in vitro data on physicochemical properties and specific absorption, distribution, metabolism, and elimination (ADME) processes are already available at early stages of drug discovery. These data about new drug candidates could be integrated/ connected in physiologically based pharmacokinetic (

Prediction of the disposition of midazol
Prediction of the disposition of midazolam in surgical patients by a physiologically based pharmacokinetic model
✍ Sven Björkman; D. Russell Wada; Britt-Marie Berling; Göran Benoni 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 243 KB

The aim of this study was to predict the disposition of midazolam in individual surgical patients by physiologically based pharmacokinetic (PBPK) modeling and explore the causes of interindividual variability. Tissue±plasma partition coef®cients (k p ) were scaled from rat to human values by a physi