Physiologically Based Pharmacokinetic Modeling of Drug Disposition in Rat and Human: A Fuzzy Arithmetic Approach
✍ Scribed by Kok-Yong Seng; Ivan Nestorov; Paolo Vicini
- Publisher
- Springer US
- Year
- 2008
- Tongue
- English
- Weight
- 612 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The biosynthetically double‐labeled lipopolysaccharide (LPS), containing ^3^H‐labeled on the fatty acyl‐chains and ^14^C‐labeled on the glucosamine of __Salmonella enterica serotype typhimurium__, was isolated from bacteria grown in proteose peptone‐beef extract (PPBE) medium in the pre
Background: Rivaroxaban is an oral Factor Xa inhibitor. The primary objective of this communication was to quantitatively predict changes in rivaroxaban exposure when individuals with varying degrees of renal impairment are co-administered with another drug that is both a P-gp and a moderate CYP3A4
## Abstract The nonlinear pharmacokinetics of capecitabine, a triple prodrug of 5‐FU preferentially activated in tumour tissues, was investigated in human cancer xenograft models. A physiologically based pharmacokinetic (PBPK) model integrating the activation process of capecitabine to 5‐FU and 5‐F