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Physiologically-Based Pharmacokinetic Modeling of Genistein in Rats, Part I: Model Development

✍ Scribed by Paul M. Schlosser; Susan J. Borghoff; Nicholas G. Coldham; John A. David; Sujit K. Ghosh

Book ID
109157491
Publisher
Springer
Year
2006
Tongue
English
Weight
573 KB
Volume
26
Category
Article
ISSN
1573-9147

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Physiologically based pharmacokinetic mo
Physiologically based pharmacokinetic modeling of cyclotrimethylenetrinitramine in male rats
✍ Kannan Krishnan; Lee C.B. Crouse; Matthew A. Bazar; Michael A. Major; Gunda Redd πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 369 KB

## Abstract A physiologically based pharmacokinetic (PBPK) model for simulating the kinetics of cyclotrimethylene trinitramine (RDX) in male rats was developed. The model consisted of five compartments interconnected by systemic circulation. The tissue uptake of RDX was described as a perfusion‐lim