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Distribution, metabolism, and elimination of phenobarbital in rats: Physiologically based pharmacokinetic model

✍ Scribed by J. M. Engasser; F. Sarhan; C. Falcoz; M. Minier; P. Letourneur; G. Siest

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
660 KB
Volume
70
Category
Article
ISSN
0022-3549

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πŸ“œ SIMILAR VOLUMES

Physiologically based pharmacokinetic mo
Physiologically based pharmacokinetic modeling of cyclotrimethylenetrinitramine in male rats
✍ Kannan Krishnan; Lee C.B. Crouse; Matthew A. Bazar; Michael A. Major; Gunda Redd πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 369 KB

## Abstract A physiologically based pharmacokinetic (PBPK) model for simulating the kinetics of cyclotrimethylene trinitramine (RDX) in male rats was developed. The model consisted of five compartments interconnected by systemic circulation. The tissue uptake of RDX was described as a perfusion‐lim