Physiologically Based Pharmacokinetic (PBPK) Modeling of Everolimus (RAD001) in Rats Involving Non-Linear Tissue Uptake

Determination of the rat tissue partitio

Determination of the rat tissue partitioning of endotoxin in vitro for physiologically-based pharmacokinetic (PBPK) modeling

✍ Ivan A. Ross; Philip P. Sapienza; Darcy E. Hanes; Widmark Johnson; Chung S. Kim 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 96 KB

## Abstract The biosynthetically double‐labeled lipopolysaccharide (LPS), containing ^3^H‐labeled on the fatty acyl‐chains and ^14^C‐labeled on the glucosamine of __Salmonella enterica serotype typhimurium__, was isolated from bacteria grown in proteose peptone‐beef extract (PPBE) medium in the pre