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Physiological aspects of ornithine decarboxylase

✍ Scribed by Uriel Bachrach


Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
717 KB
Volume
2
Category
Article
ISSN
0263-6484

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Crystals of truncated (A425-461) pyridoxal-5'-phosphate (PLP)-dependent mouse ornithine decarboxylase (mOrnDC') have been obtained that diffract to 2.2 resolution (P2,2,2, a = 119.5 A, b = 74.3 A, c = 46.1 A). OrnDC produces putrescine, which is the precursor for the synthesis of polyamines in eukar

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## BACKGROUND. Ornithine decarboxylase (ODC) is a key rate-limiting enzyme in polyamine biosynthesis. Several studies using an enzyme assay revealed that the ODC activity was higher in tumor tissue than in normal tissue. However, there is little information on the mRNA status of ODC in surgical sp