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Expression of ornithine decarboxylase mRNA in gastric carcinoma

✍ Scribed by Masaki Mori; Masayuki Honda; Kenji Shibuta; Kinya Baba; Hideaki Nakashima; Masaru Haraguchi; Fumio Koba; Hiroaki Ueo; Keizo Sugimachi; Tsuyoshi Akiyoshi


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
422 KB
Volume
77
Category
Article
ISSN
0008-543X

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✦ Synopsis


BACKGROUND.

Ornithine decarboxylase (ODC) is a key rate-limiting enzyme in polyamine biosynthesis. Several studies using an enzyme assay revealed that the ODC activity was higher in tumor tissue than in normal tissue. However, there is little information on the mRNA status of ODC in surgical specimens. ODC is a transcriptional target gene of c-myc.


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