𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Physical model evaluation of topical prodrug delivery—simultaneous transport and bioconversion of vidarabine-5′-valerate V: Mechanistic analysis of influence of nonhomogeneous enzyme distributions in hairless mouse skin

✍ Scribed by Cheng der Yu; Neal A. Gordon; Jeffrey L. Fox; William I. Higuchi; Norman F. H. Ho


Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
592 KB
Volume
69
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Physical model evaluation of topical pro
✍ Cheng Der Yu; Jeffrey L. Fox; Norman F. H. Ho; William I. Higuchi 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 599 KB

A physical model approach to the topical delivery of a vidarabine ester prodrug was investigated. It involved modeling, theoretical simulations, experimental method development for factoring and quantifying parameters, and, finally, employment of the deduced parameters to determine the steady-state

Physical model evaluation of topical pro
✍ Cheng der Yu; William I. Higuchi; Norman F. H. Ho; Jeffrey L. Fox; Gordon L. Fly 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB

The permeation behavior of 3H-vidarabine (3H-9-P-D-arabinofuranosyladenine) and 14C-n-pentanol through different strata of hairless mouse skin was studied using a diffusion cell at 37O under steady-state conditions. Partition coefficients for the skin components versus 0.9% aqueous NaCl solution als