Physical model evaluation of topical prodrug delivery—simultaneous transport and bioconversion of vidarabine-5′-valerate IV: Distribution of esterase and deaminase enzymes in hairless mouse skin

Physical model evaluation of topical pro

Physical model evaluation of topical prodrug delivery—simultaneous transport and bioconversion of vidarabine-5′-valerate III: Permeability differences of vidarabine and n-pentanol in components of hairless mouse skin

✍ Cheng der Yu; William I. Higuchi; Norman F. H. Ho; Jeffrey L. Fox; Gordon L. Fly 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB

The permeation behavior of 3H-vidarabine (3H-9-P-D-arabinofuranosyladenine) and 14C-n-pentanol through different strata of hairless mouse skin was studied using a diffusion cell at 37O under steady-state conditions. Partition coefficients for the skin components versus 0.9% aqueous NaCl solution als