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Physical Basis of Structural and Catalytic Zn-Binding Sites in Proteins

✍ Scribed by Yu-ming Lee; Carmay Lim

Book ID
116663779
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
637 KB
Volume
379
Category
Article
ISSN
0022-2836

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We have developed a strategy for grafting a protein-protein interface based on the known crystal structure of a native ligand and receptor proteins in a complex. The key interaction residues at the ligand protein binding interface are transferred onto a scaffold protein so that the mutated scaffold