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Sequence and structural analysis of binding site residues in protein–protein complexes

✍ Scribed by M. Michael Gromiha; Kiyonobu Yokota; Kazuhiko Fukui

Book ID
116542222
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
587 KB
Volume
46
Category
Article
ISSN
0141-8130

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We have developed a strategy for grafting a protein-protein interface based on the known crystal structure of a native ligand and receptor proteins in a complex. The key interaction residues at the ligand protein binding interface are transferred onto a scaffold protein so that the mutated scaffold