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Photoregulation of the DNA Polymerase Reaction by Oligonucleotides Bearing an Azobenzene

✍ Scribed by Akira Yamazawa; Xingguo Liang; Hiroyuki Asanuma; Makoto Komiyama


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
81 KB
Volume
39
Category
Article
ISSN
0044-8249

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The duplex-forming activities of oligonucleotides can be photomodulated by incorporation of an azobenzene unit. Upon isomerizing the trans-azobenzene to the cis form by irradiation with UV light, the T m value of the duplex (with the complementary DNA) is lowered so that the duplex is dissociated. T

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