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PHOTOFRIN II PHOTOSENSITIZATION IS MUTAGENIC AT THE tk LOCUS IN MOUSE L5178Y CELLS

✍ Scribed by Ronald M. Rerko; Marian E. Clay; Antonio R. Antunez; Nancy L. Oleinick; Helen H. Evans

Book ID: 114896308
Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 605 KB
Volume: 55
Category: Article
ISSN: 0031-8655
DOI: 10.1111/j.1751-1097.1992.tb04211.x

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One of the mammalian cell gene-mutation assays that has been used extensively for mutagenicity studies is the L5178Y/TK+'--3.7.2C mouse lymphoma assay Oberly et al., 19841. This assay measures forward mutation at the functionally heterozygous thymidine kinase (rk) locus based on resistance to trifl