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Mutagenic responses of L5178Y mouse cells at the tk and hprt loci

✍ Scribed by D.B. McGregor; C. Riach; P. Cattanach; I. Edwards; W. Shepherd; W.J. Caspary


Book ID
117587827
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
545 KB
Volume
10
Category
Article
ISSN
0887-2333

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One of the mammalian cell gene-mutation assays that has been used extensively for mutagenicity studies is the L5178Y/TK+'--3.7.2C mouse lymphoma assay Oberly et al., 19841. This assay measures forward mutation at the functionally heterozygous thymidine kinase (rk) locus based on resistance to trifl