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Isolation and characterization of mutants at the APRT locus in the L-5178Y TK+/TK− mouse lymphoma cell line

✍ Scribed by Umnarj Paeratakul; Milton W. Taylor


Book ID
114071184
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
709 KB
Volume
160
Category
Article
ISSN
0027-5107

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One of the mammalian cell gene-mutation assays that has been used extensively for mutagenicity studies is the L5178Y/TK+'--3.7.2C mouse lymphoma assay Oberly et al., 19841. This assay measures forward mutation at the functionally heterozygous thymidine kinase (rk) locus based on resistance to trifl