Photocontrol of Protein Activity Mediated by the Cleavage Reaction of a Split Intein
✍ Scribed by Jens Binschik; Dr. Joachim Zettler; Prof. Dr. Henning D. Mootz
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 484 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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Protein splicing in trans results in the ligation of two protein or peptide segments linked to appropriate intein fragments. We have characterized the trans-splicing reaction mediated by a naturally expressed, approximately 100-residue N-terminal fragment of the Mycobacterium tuberculosis intein and
The cyclometalation reaction [1] constitutes one of the first known examples of C ± H bond activation, which is a major achievement of organometallic chemistry. [2] Of particular interest is the cyclometalation of a pendant aromatic ring, a process that constitutes a good model for C ± H activation